| Date | Location | Result | |
| 3/4/22 | Medford, MA (Tufts Univ.) | DeSales 78, Cortland 52 | Box score |
| 2/26/22 | Cortland, NY (Corey Gym) | New Paltz 66, Cortland 63 | Box score |
| 2/25/22 | Cortland, NY (Corey Gym) | Cortland 69, Oneonta 52 | Box score |
| 2/19/22 | Cortland, NY (Corey Gym) | Cortland 69, Geneseo 56 | Box score |
| 2/18/22 | Cortland, NY (Corey Gym) | Cortland 97, Buffalo St. 66 | Box score |
| 2/15/22 | Buffalo, NY (Buffalo St. Sports Arena) | Buffalo St. 65, Cortland 58 | Box score |
| 2/12/22 | New Paltz, NY (Hawk Center) | New Paltz 51, Cortland 42 | Box score |
| 2/11/22 | Oneonta, NY (Dewar Arena) | Cortland 58, Oneonta 39 | Box score |
| 2/5/22 | Cortland, NY (Corey Gym) | Cortland 72, Potsdam 51 | Box score |
| 2/4/22 | Cortland, NY (Corey Gym) | Cortland 81, Plattsburgh 45 | Box score |
| 2/1/22 | Cortland, NY (Corey Gym) | Cortland 76, Fredonia 48 | Box score |
| 1/29/22 | Cortland, NY (Corey Gym) | Cortland 77, Oneonta 65 | Box score |
| 1/28/22 | Cortland, NY (Corey Gym) | Cortland 62, New Paltz 46 | Box score |
| 1/22/22 | Cortland, NY (Corey Gym) | Cortland 55, Oswego 49 | Box score |
| 1/18/22 | Brockport, NY (Vlogianitis Gym) | Cortland 44, Brockport 31 | Box score |
| 1/14/22 | Potsdam, NY (Jerry Welsh Gym) | Cortland 64, Potsdam 55 | Box score |
| 1/13/22 | Plattsburgh, NY (Memorial Hall) | Cortland 81, Plattsburgh 48 | Box score |
| 12/12/21 | Utica, NY (Campus Center Gym) | Cortland 68, SUNY Poly 46 | Box score |
| 12/8/21 | Geneseo, NY (Schrader Gym) | Cortland 67, Geneseo 60 | Box score |
| 12/4/21 | Fredonia, NY (Dods Hall) | Cortland 66, Fredonia 60 | Box score |
| 12/3/21 | Cortland, NY (Corey Gym) | Cortland 82, Brockport 52 | Box score |
| 11/30/21 | Oswego, NY (Max Ziel Gym) | Cortland 67, Oswego 53 | Box score |
| 11/23/21 | Cortland, NY (Corey Gym) | Cortland 53, Hamilton 39 | Box score |
| 11/19/21 | Cortland, NY (Corey Gym) | Cortland 68, Ithaca 64 | Box score |
| 11/16/21 | Oneonta, NY (Lambros Arena) | Hartwick 55, Cortland 49 | Box score |
| 11/13/21 | Madison, NJ (Baldwin Gymnasium) | Cortland 79, Neumann 60 | Box score |
| 11/12/21 | Madison, NJ (Baldwin Gymnasium) | Misericordia 73, Cortland 69 | Box score |